Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults Martha Clare Morris, ScD1; John Brockman, PhD2; Julie A. Schneider, MD, MPH3,4,5; Yamin Wang, PhD1; David A. Bennett, MD3,4; Christy C. Tangney, PhD6; Ondine van de Rest, PhD7 [+] Author Affiliations JAMA. 2016;315(5):489-497. doi:10.1001/jama.2015.19451. Importance  Seafood consumption is promoted for its many health benefits even though its contamination by mercury, a known […]

Overprescribing Anticholinergics May Hurt Recovery in Elderly http://tinyurl.com/z9gbut4 UNIVERSITY PARK, Pa. — During rehabilitation following an acute hospital stay, medications that block neurotransmitters may be overprescribed to older patients suffering from delirium superimposed on dementia, according to health researchers. Specifically, strong anticholinergic medications may be prescribed to older adults when there are other suitable options. […]

Can Vitamin D Benefit Patients with Prediabetes? No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial Henrik Wagner1⇑, Michael Alvarsson1, Buster Mannheimer2, Marie Degerblad1 and Claes Göran Östenson1 http://care.diabetesjournals.org/content/early/2016/01/07/dc15 -1057.abstract Abstract OBJECTIVE There has been conflicting evidence regarding the potential role of vitamin […]

True Risk of Serious Harms with Antidepressants Still Uncertain   Objective To study serious harms associated with selective serotonin and serotonin-norepinephrine reuptake inhibitors. Design Systematic review and meta-analysis. Main outcome measures Mortality and suicidality. Secondary outcomes were aggressive behaviour and akathisia. Data sources Clinical study reports for duloxetine, fluoxetine, paroxetine, sertraline, and venlafaxine obtained from the European and UK […]

Quetiapine safety in older adults? Journal of Clinical Pharmacy and Therapeutics Volume 41,  Issue 1, pages 7–18, February 2016 http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12357/abstract Abstract WHAT IS KNOWN AND OBJECTIVE: Quetiapine is a second-generation antipsychotic that is commonly prescribed for a range of approved and off-label indications in older adults. However, little is known about its safety in this population. The available […]