Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats.

Posted on April 23, 2019 by Maurice Preter MD

Curr Protoc Neurosci. 2003 Nov;Chapter 9:Unit 9.17.
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Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats.

Sajdyk TJ, Keim SR, Thielen SR, Fitz SD, Shekhar A.

Indiana University Medical Center, Indianapolis, Indiana, USA.

This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.

PMID: 18428590 [PubMed – indexed for MEDLINE]